Clark's rule is a formula used to determine pediatric doses of over the counter medicine.
The formula says
The weight of a child divided by 150 multiplied by the adult dose is the same as the child dose
if an adult dose of acetaminophen is 1,000 mg and a child weighs less than 90 pounds, what is
the recommended range of doses?
A. x≤ 600
B. x ≥ 600
C. 500 D. 500 ≤x≤ 600

500 ≤x≤ 600  is the recommended range of doses. Typically, a phase I or early phase II clinical trial involves dose range.

To solve this problem using Clark's rule, we need to determine the range of pediatric doses for a child who weighs less than 90 pounds and for whom the adult dose is 1,000 mg.

A mathematical formula known as Clark's rule is used in medicine to determine the right dosage of medication for patients aged 2 to 17 depending on their weight and the recommended adult dose.

First, we can use the formula provided to calculate the child dose:

Child dose = (Weight of child / 150) * Adult dose

Since the weight of the child is less than 90 pounds, we can set the weight of the child to the minimum value in the range, which is 50 pounds. This gives us:

Child dose = (50 / 150) * 1000 mg

= 333.33 mg

Next, we can set the weight of the child to the maximum value in the range, which is 89 pounds. This gives us:

Child dose = (89 / 150) * 1000 mg

= 593.33 mg

Therefore, the recommended range of doses for a child who weighs less than 90 pounds and for whom the adult dose is 1,000 mg is 500 mg ≤ x ≤ 600 mg.

So, the correct answer is D. 500 ≤x≤ 600.

To learn more about dosage refer :

https://brainly.com/question/7152738

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Appeasement is the policy of making concessions in order to avoid a conflict. In the 1930’s it became the dominant French and British international policy toward Germany and other aggressive nations. The League of Nations had been created to peacefully resolve international disputes. However, without the United States as a member of any military force, it was ineffective at preventing belligerent nations from violating agreements.
When Italy invaded Ethiopia and Japan invaded Manchuria and China, the League could do nothing but impose economic sanctions. Adolf Hitler realized that democracies sought to avoid a confrontation and continued to test their limits. First, he remilitarized the Rhineland then turned his sights on a region of German speakers in Czechoslovakia known as the Sudetenland.
In September 1938, British Prime Minister Neville Chamberlain met with Hitler in Munich to discuss his demands. The Sudetenland held most of Czechoslovakia’s border defenses, heavy industries, and banks. Without consulting Czech authorities, however, Chamberlain pledged to give Germany all the areas with a German population of more than 50%. France was persuaded to agree. Hitler then demanded all the Sudetenland and Britain and France agreed to his demands. Chamberlain returned to Great Britain claiming he had secured “peace for our time.”
Appeasement was not without its critics, however. Winston Churchill believed in a firm stand against Nazi Germany. When Germany seized the remainder of Czechoslovakia in March 1939, it was clear that appeasement had failed. Chamberlain resigned and Churchill became the new Prime Minister of Great Britain.
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“When I think of those four terrible years and I think of the 7million young men who were killed, the 13 million who were maimed and mutilated… I have said before, and what I say now to all the world – in war, whichever side may call itself the victor, there are no winners, but all are losers. It is those thoughts which have made me feel that it was my prime duty to strain every nerve to avoid a repetition of the Great War in Europe.”
― Neville Chamberlain
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“An appeaser is one who feeds a crocodile, hoping it will eat him last.”
― Winston S. Churchill


Directions: After reading about appeasement, answer the following questions.
1. What is the best definition for “belligerent” as it is used in the 1st paragraph? Highlight your answer
a. Weak
b. Hostile
c. Peaceful
d. Isolationist
2. What made the League of Nations ineffective?



3. What was Neville Chamberlain’s justification for his policy of appeasement?



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a. Intimidating
b. Wise
c. Gullible
d. Bold
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